As the game's most powerful enemy, the Giganotosaurus has no true weakness at all, even Anti-Tank Rifle and Solid Cannon don't seem to do real damage to the dinosaur. The Giganotosaurus' roar can and will send the characters flying away, as opposed to the Tyrannosaurus' roar which only disorientates Dylan/Regina. The dinosaur can also use its massive jaws to slam the platform where the character is, dealing moderate damage.
The first battle against the Giganotosaurus commenced in the Missile Silo facility. Regina must use the two flame throwers located on the platform by first turning it on, then use Regina's stungun to release the flames to the Giganotosaurus. Repeat the process several times until the huge beast is down and proceed to do the required task of the chapter.
The next and final battle takes place in the time gate laboratory, where a self-destruct mechanism is triggered. The player's objective is to initiate a satellite to fire a laser beam to the Giganotosaurus to defeat her. Dylan must activate several computers in order to fire the beam, with the Giganotosaurus trying to stop him by any means necessary.