The camera angles in the CG cutscenes were directed by a professional film director.
The game is set on a starship because Capcom Production Studio 4 wanted something fresh that wasn't just a laboratory.
It was made an Xbox-exclusive title when that console was judged to be better at rendering graphics than the PlayStation 2. Hiroyuki Kobayashi considered a PlayStation port of the game to be "impossible".
The game was announced during the Xbox Conference in June 2002. Its status as an Xbox-exclusive was re-affirmed in December.
On April 17, 2003, Microsoft announced their intention to release a special edition Xbox console with a DVD playback kit included. The edition was dubbed the "Dino Crisis 3 Limited Box". Later in the year, it was moved a week ahead in its release date to September 16.
On April 28, Sonya Hart's playability was confirmed by Famitsu. Soon after in the beginning of May, the game's official Japanese website was updated soon after to introduce the seventeen year old "Caren", as well as Sonya.