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When Rick says to Regina "This is just like that movie" (referring to the dinosaurs they encounter), he is referring to the 1993 blockbuster film, Jurassic Park. Coincidentally, Jurassic Park III featured a character named Cooper who suffered a similar fate as the Dino Crisis character Cooper.
When the prehistoric costume is equipped, the guns Regina has change form. For example, the grenade launcher turns into a mummified coelacanth which becomes revived with the grenade launcher upgrade.
On some of the crates around the island, the player may see the insignia of the Umbrella Corporation from Resident Evil. Coincidentally, both Dino Crisis and Resident Evil are made by Capcom. with Capcom Production Studio 4 and Shinji Mikami working on this title.
In the non-Asian releases of Dino Crisis, the scene where the tyrannosaur kills Cooper is censored slightly. In the Japanese version, the lower half of his torso goes flying off and the tyrannosaur swallows the upper half. The lower half of his torso flying is cut out in all the other versions, making it appear as if the Rex swallowed him whole.